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A summary of studies included in this review is given in Table 1. A bivariate meta-regression model was used to identify sources of heterogeneity in all figures (Fig. 4, Fig. 6, Fig. 7, Fig. 9, Fig. 10, Fig. 11, Fig. 12, Fig. 13, Fig. 14, Fig. 15, Fig. 16, Fig. 17, Fig. 18, Fig. 19, Fig. 20, Fig. 21, Fig. 22, Fig. 23, Fig. 24, Fig. 25, Fig. 26, Fig. 27, Fig. 28, Fig. 29, Fig. 30, Fig. 31, Fig. 32, Fig. 33, Fig. 34, Fig. 35, Fig. 36, Fig. 37, Fig. 38, Fig. 39, Fig. 40, Fig. 41, Fig. 42, Fig. 43, Fig. 44, Fig. 45, Fig. 46, Fig. 47, Fig. 48, Fig. 49, Fig. 50, Fig. 51, Fig. 52). Bivariate model was chosen over hierarchical random-effects model due to low levels of correlation between variables, and the bivariate fixed-effects model performing equally well, with identical parameter estimates. All significance tests are from the bivariate fixed-effects model as recommended by the Cochrane Handbook for Systematic Reviews of Interventions50. These findings were consistent between the 2 reviewers when screening and subsequently assessing bias and heterogeneity. The bivariate meta-regression model is described in Supplementary File 1. A summary of forest plots is given in Supplementary File 2. Forest plots of sensitivity, specificity, LR+, LR- and DOR are provided in Supplementary File 3. Forest plots of post-test probability, AUC (or ROC), positive predictive value (PPV), negative predictive value (NPV), and diagnostic odds ratio (DOR) are provided in Supplementary File 4. Forest plots of kappa are provided in Supplementary File 5. Forest plots of sensitivity, specificity, PPV, NPV, and DOR are provided in Supplementary File 6. Forest plots of positive likelihood ratio (LR+), negative likelihood ratio (LR-), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) are provided in Supplementary File 7. Forest plots of kappa are provided in Supplementary File 8.
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Atomic Blonde is a 2017 American spy action film directed by David Leitch and starring Charlize Theron. Written by Theron, Tom O'Neil, and John Brion, it is the fourth installment of the Mad Max franchise, and a reboot of the character for a new generation. The film follows the story of Lorraine Broughton (Theron), a former MI6 agent, who is recruited by the CIA to rescue her former partner, Anarchy (Joel Kinnaman), from a Russian prison.
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